PDBsum entry 4yju

Transferase

PDB id: 4yju

Contents

Protein chain

267 a.a.

Ligands

4DO

Waters ×279

PDB id:

4yju

Name:

Transferase

Title:

The kinase domain of human spleen tyrosine (syk) in complex with gtc000249

Structure:

Tyrosine-protein kinase syk. Chain: a. Fragment: unp residues 355-635. Synonym: spleen tyrosine kinase,p72-syk. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: syk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9

Resolution:

1.67Å R-factor: 0.168 R-free: 0.201

Authors:

D.O.Somers,M.Neu,J.Stuckey

Key ref:

J.Liddle et al. (2011). Discovery of GSK143, a highly potent, selective and orally efficacious spleen tyrosine kinase inhibitor. Bioorg Med Chem Lett, 21, 6188-6194. PubMed id: 21903390

Date:

03-Mar-15 Release date: 30-Sep-15

Protein chain

P43405  (KSYK_HUMAN) -  Tyrosine-protein kinase SYK from Homo sapiens

Seq: 635 a.a.

Struc: 267 a.a.

Enzyme reactions

• Enzyme class: E.C.2.7.10.2 - non-specific protein-tyrosine kinase.
• Reaction: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H⁺

Molecule diagrams generated from .mol files obtained from the KEGG ftp site

Added reference

Bioorg Med Chem Lett 21:6188-6194 (2011)

PubMed id: 21903390

Discovery of GSK143, a highly potent, selective and orally efficacious spleen tyrosine kinase inhibitor.

J.Liddle, F.L.Atkinson, M.D.Barker, P.S.Carter, N.R.Curtis, R.P.Davis, C.Douault, M.C.Dickson, D.Elwes, N.S.Garton, M.Gray, T.G.Hayhow, C.I.Hobbs, E.Jones, S.Leach, K.Leavens, H.D.Lewis, S.McCleary, M.Neu, V.K.Patel, A.G.Preston, C.Ramirez-Molina, T.J.Shipley, P.A.Skone, N.Smithers, D.O.Somers, A.L.Walker, R.J.Watson, G.G.Weingarten.

ABSTRACT

No abstract given.