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UniProt functional annotation for Q12114 | ||
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| UniProt code: Q12114. |
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| Organism: | |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). |
| Taxonomy: | |
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. |
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| Function: | |
Component of the CHS5/6 complex which mediates export of specific cargo proteins, including chitin synthase CHS3. Also involved in targeting FUS1 to sites of polarized growth. {ECO:0000269|PubMed:12912901, ECO:0000269|PubMed:15715908, ECO:0000269|PubMed:16498409, ECO:0000269|PubMed:16818716, ECO:0000269|PubMed:16855022, ECO:0000269|PubMed:17000877, ECO:0000269|PubMed:8197125, ECO:0000269|PubMed:9111317}. |
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| Subunit: | |
Component of the CHS5/6 complex composed of the 4 CHAPS proteins BCH1, BCH2, BUD7, and CHS6 as well as at least CHS5 and GTP- bound ARF1. The complex interacts with the cargo protein CHS3. {ECO:0000269|PubMed:16498409, ECO:0000269|PubMed:16855022, ECO:0000269|PubMed:17000877}. |
| Subcellular location: | |
Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:16498409, ECO:0000269|PubMed:17000877, ECO:0000269|PubMed:9008706}; Peripheral membrane protein {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:16498409, ECO:0000269|PubMed:17000877, ECO:0000269|PubMed:9008706}. Note=Trans-Golgi network location requires interaction with myristoylated GTP-bound ARF1 for the recruitment to the membranes. |
| Disruption phenotype: | |
Abolishes CHS3 localization to the bud neck and plasma membrane, with increased protein localization to intracellular vesicles. {ECO:0000269|PubMed:28346351}. |
| Miscellaneous: | |
Present with 172 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}. |
| Similarity: | |
Belongs to the CHS5 family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.