UniProt functional annotation for P59823



	UniProt functional annotation for P59823

UniProt code: P59823.

Organism: Mus musculus (Mouse).

Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus.

Function: May regulate secretion and presynaptic differentiation through inhibition of the activity of N-type voltage-gated calcium channel. May activate the MAP kinase JNK (By similarity). Plays a role in neurite outgrowth (By similarity). During dendritic spine formation can bidirectionally induce pre- and post-synaptic differentiation of neurons by trans-synaptically binding to PTPRD (PubMed:25908590, PubMed:21940441). {ECO:0000250|UniProtKB:P59824, ECO:0000250|UniProtKB:Q9NZN1, ECO:0000269|PubMed:21940441, ECO:0000269|PubMed:25908590}.

Catalytic activity: Reaction=H2O + NAD(+) = ADP-D-ribose + H(+) + nicotinamide; Xref=Rhea:RHEA:16301, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17154, ChEBI:CHEBI:57540, ChEBI:CHEBI:57967; EC=3.2.2.6; Evidence={ECO:0000255|PROSITE-ProRule:PRU00204}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:16302; Evidence={ECO:0000255|PROSITE-ProRule:PRU00204};

Subunit: Homodimer (PubMed:25908590). Interacts (calcium-independent) with NCS1/FREQ (By similarity). Interacts (via the first immunoglobilin domain) with PTPRD (via the second immunoglobilin domain); this interaction is PTPRD-splicing-dependent and induces pre- and post- synaptic differentiation of neurons and is required for IL1RAPL1- mediated synapse formation (PubMed:25908590, PubMed:21940441). {ECO:0000250|UniProtKB:Q9NZN1, ECO:0000269|PubMed:21940441, ECO:0000269|PubMed:25908590}.

Subcellular location: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Cytoplasm {ECO:0000250}. Cell projection, axon {ECO:0000269|PubMed:21940441}. Cell projection, dendrite {ECO:0000269|PubMed:21940441}. Note=May localize to the cell body and growth cones of dendrite-like processes.

Tissue specificity: Detected in total brain extracts, olfactory bulb, hippocampus and striatum (at protein level). {ECO:0000269|PubMed:12783849}.

Domain: The TIR domain mediates NAD(+) hydrolase (NADase) activity. Self-association of TIR domains is required for NADase activity. {ECO:0000255|PROSITE-ProRule:PRU00204}.

Similarity: Belongs to the interleukin-1 receptor family. {ECO:0000305}.

Annotations taken from UniProtKB at the EBI.


Organism:		Mus musculus (Mouse).
Taxonomy:		Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus.



Function:		May regulate secretion and presynaptic differentiation through inhibition of the activity of N-type voltage-gated calcium channel. May activate the MAP kinase JNK (By similarity). Plays a role in neurite outgrowth (By similarity). During dendritic spine formation can bidirectionally induce pre- and post-synaptic differentiation of neurons by trans-synaptically binding to PTPRD (PubMed:25908590, PubMed:21940441). {ECO:0000250\|UniProtKB:P59824, ECO:0000250\|UniProtKB:Q9NZN1, ECO:0000269\|PubMed:21940441, ECO:0000269\|PubMed:25908590}.


Catalytic activity:		Reaction=H2O + NAD(+) = ADP-D-ribose + H(+) + nicotinamide; Xref=Rhea:RHEA:16301, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17154, ChEBI:CHEBI:57540, ChEBI:CHEBI:57967; EC=3.2.2.6; Evidence={ECO:0000255\|PROSITE-ProRule:PRU00204}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:16302; Evidence={ECO:0000255\|PROSITE-ProRule:PRU00204};
Subunit:		Homodimer (PubMed:25908590). Interacts (calcium-independent) with NCS1/FREQ (By similarity). Interacts (via the first immunoglobilin domain) with PTPRD (via the second immunoglobilin domain); this interaction is PTPRD-splicing-dependent and induces pre- and post- synaptic differentiation of neurons and is required for IL1RAPL1- mediated synapse formation (PubMed:25908590, PubMed:21940441). {ECO:0000250\|UniProtKB:Q9NZN1, ECO:0000269\|PubMed:21940441, ECO:0000269\|PubMed:25908590}.
Subcellular location:		Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Cytoplasm {ECO:0000250}. Cell projection, axon {ECO:0000269\|PubMed:21940441}. Cell projection, dendrite {ECO:0000269\|PubMed:21940441}. Note=May localize to the cell body and growth cones of dendrite-like processes.
Tissue specificity:		Detected in total brain extracts, olfactory bulb, hippocampus and striatum (at protein level). {ECO:0000269\|PubMed:12783849}.
Domain:		The TIR domain mediates NAD(+) hydrolase (NADase) activity. Self-association of TIR domains is required for NADase activity. {ECO:0000255\|PROSITE-ProRule:PRU00204}.
Similarity:		Belongs to the interleukin-1 receptor family. {ECO:0000305}.