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PDBsum entry 4y95
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protein ligands Protein-protein interface(s) links
Transferase PDB id
4y95

 

 

 

 

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JSmol PyMol  
Contents
Protein chains
266 a.a.
Ligands
746 ×4
GOL ×8
BME ×3
PE4 ×2
Waters ×968
PDB id:
4y95
Name: Transferase
Title: Crystal structure of the kinase domain of bruton's tyrosine kinase with mutations in the activation loop
Structure: Non-specific protein-tyrosine kinase. Chain: a, b, c, d. Fragment: kinase domain (unp 395-659). Engineered: yes. Mutation: yes
Source: Bos taurus. Bovine. Organism_taxid: 9913. Gene: btk. Expressed in: escherichia coli. Expression_system_taxid: 562
Resolution:
1.60Å     R-factor:   0.155     R-free:   0.184
Authors: Q.Wang,C.E.Rosen,J.Kuriyan
Key ref: Q.Wang et al. (2015). Autoinhibition of Bruton's tyrosine kinase (Btk) and activation by soluble inositol hexakisphosphate. Elife, 4, . PubMed id: 25699547 DOI: 10.7554/eLife.06074
Date:
16-Feb-15     Release date:   18-Mar-15    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chains
Pfam   ArchSchema ?
Q3ZC95  (Q3ZC95_BOVIN) -  Tyrosine-protein kinase from Bos taurus
Seq:
Struc: 		 
Seq:
Struc: 		659 a.a.
266 a.a.*
Key:    PfamA domain  Secondary structure  CATH domain
* PDB and UniProt seqs differ at 10 residue positions (black crosses)

 Enzyme reactions 
   Enzyme class: E.C.2.7.10.2  - non-specific protein-tyrosine kinase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H+
L-tyrosyl-[protein]
 + ATP
 = O-phospho-L-tyrosyl-[protein]
 + ADP
 + H(+)
Molecule diagrams generated from .mol files obtained from the KEGG ftp site

 

 
    Added reference    
 
 
DOI no: 10.7554/eLife.06074 Elife 4: (2015)
PubMed id: 25699547  
 
 
Autoinhibition of Bruton's tyrosine kinase (Btk) and activation by soluble inositol hexakisphosphate.
Q.Wang, E.M.Vogan, L.M.Nocka, C.E.Rosen, J.A.Zorn, S.C.Harrison, J.Kuriyan.
 
  ABSTRACT  
 
No abstract given.

 

 

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