PDBsum entry 4y94

Transferase

PDB id: 4y94

Contents

Protein chains

149 a.a.

157 a.a.

Ligands

IHP ×6

Metals

_ZN ×4

Waters ×43

PDB id:

4y94

Name:

Transferase

Title:

Crystal structure of the ph-th module of bruton's tyrosine kinase bound to inositol hexakisphosphate

Structure:

Non-specific protein-tyrosine kinase. Chain: b, c, a, d. Fragment: ph domain (unp residues 1-170). Engineered: yes

Source:

Bos taurus. Bovine. Organism_taxid: 9913. Gene: btk. Expressed in: escherichia coli. Expression_system_taxid: 562

Resolution:

2.40Å R-factor: 0.231 R-free: 0.255

Authors:

Q.Wang,J.Kuriyan

Key ref:

Q.Wang et al. (2015). Autoinhibition of Bruton's tyrosine kinase (Btk) and activation by soluble inositol hexakisphosphate. Elife, 4, . PubMed id: 25699547 DOI: 10.7554/eLife.06074

Date:

16-Feb-15 Release date: 18-Mar-15

Protein chain

Q3ZC95  (Q3ZC95_BOVIN) -  Tyrosine-protein kinase from Bos taurus

Seq: 659 a.a.

Struc: 149 a.a.

Protein chains

Q3ZC95  (Q3ZC95_BOVIN) -  Tyrosine-protein kinase from Bos taurus

Seq: 659 a.a.

Struc: 157 a.a.

Enzyme reactions

• Enzyme class: Chains B, C, A, D: E.C.2.7.10.2 - non-specific protein-tyrosine kinase.
• Reaction: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H⁺

Molecule diagrams generated from .mol files obtained from the KEGG ftp site

Added reference

DOI no: 10.7554/eLife.06074

Elife 4: (2015)

PubMed id: 25699547

Autoinhibition of Bruton's tyrosine kinase (Btk) and activation by soluble inositol hexakisphosphate.

Q.Wang, E.M.Vogan, L.M.Nocka, C.E.Rosen, J.A.Zorn, S.C.Harrison, J.Kuriyan.

ABSTRACT

No abstract given.