PDBsum entry 4y7a

Hydrolase

PDB id: 4y7a

Contents

Protein chains

234 a.a.

53 a.a.

Ligands

987

Metals

_CA

_MG

Waters ×215

PDB id:

4y7a

Name:

Hydrolase

Title:

Factor xa complex with gtc000422

Structure:

Coagulation factor x. Chain: a. Synonym: stuart factor,stuart-prower factor, activated factor xa heavy chain. Coagulation factor x. Chain: b. Fragment: unp residues 46-179. Synonym: stuart factor,stuart-prower factor, factor x light chain. Ec: 3.4.21.6

Source:

Homo sapiens. Human. Organism_taxid: 9606. Organism_taxid: 9606

Resolution:

1.99Å R-factor: 0.191 R-free: 0.236

Authors:

M.A.Convery,R.J.Young,S.Senger,J.N.Hamblin,C.Chan,J.R.Toomey, N.S.Watson

Key ref:

M.A.Convery et al. Factor xa complex with gtc000422. To be published, .

Date:

13-Feb-15 Release date: 30-Sep-15

Protein chain

P00742  (FA10_HUMAN) -  Coagulation factor X from Homo sapiens

Seq: 488 a.a.

Struc: 234 a.a.

Protein chain

P00742  (FA10_HUMAN) -  Coagulation factor X from Homo sapiens

Seq: 488 a.a.

Struc: 53 a.a.

Enzyme reactions

• Enzyme class: Chains A, B: E.C.3.4.21.6 - coagulation factor Xa.
• Reaction: Preferential cleavage: Arg-|-Thr and then Arg-|-Ile bonds in prothrombin to form thrombin.