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PDBsum entry 4xw2
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Immune system
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PDB id
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4xw2
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PDB id:
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| Name: |
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Immune system
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Title:
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Structural basis for simvastatin competitive antagonism of complement receptor 3
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Structure:
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Integrin alpha-m. Chain: a. Fragment: unp residues 145-337. Synonym: cd11 antigen-like family member b,cr-3 alpha chain,cell surface glycoprotein mac-1 subunit alpha,leukocyte adhesion receptor mo1,neutrophil adherence receptor. Engineered: yes. Other_details: the discrepancies come from the expression vector
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Source:
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Homo sapiens. Human. Organism_taxid: 9606. Gene: itgam, cd11b, cr3a. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008
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Resolution:
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2.00Å
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R-factor:
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0.192
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R-free:
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0.232
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Authors:
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G.Bajic,M.R.Jensen,T.Vorup-Jensen,G.R.Andersen
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Key ref:
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M.R.Jensen
et al.
(2016).
Structural Basis for Simvastatin Competitive Antagonism of Complement Receptor 3.
J Biol Chem,
291,
16963-16976.
PubMed id:
DOI:
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Date:
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28-Jan-15
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Release date:
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13-Jan-16
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PROCHECK
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Headers
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References
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P11215
(ITAM_HUMAN) -
Integrin alpha-M from Homo sapiens
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Seq:
Struc:
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1152 a.a.
184 a.a.
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Key: |
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PfamA domain |
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Secondary structure |
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CATH domain |
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DOI no:
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J Biol Chem
291:16963-16976
(2016)
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PubMed id:
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Structural Basis for Simvastatin Competitive Antagonism of Complement Receptor 3.
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M.R.Jensen,
G.Bajic,
X.Zhang,
A.K.Laustsen,
H.Koldsø,
K.K.Skeby,
B.Schiøtt,
G.R.Andersen,
T.Vorup-Jensen.
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ABSTRACT
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Links
