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PDBsum entry 4xst
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Hormone/hormone receptor
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PDB id
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4xst
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References listed in PDB file
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Key reference
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Title
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Structural congruency of ligand binding to the insulin and insulin/type 1 insulin-Like growth factor hybrid receptors.
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Authors
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J.G.Menting,
C.F.Lawrence,
G.K.Kong,
M.B.Margetts,
C.W.Ward,
M.C.Lawrence.
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Ref.
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Structure, 2015,
23,
1271-1282.
[DOI no: ]
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PubMed id
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Abstract
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The homodimeric insulin and type 1 insulin-like growth factor receptors (IR and
IGF-1R) share a common architecture and each can bind all three ligands within
the family: insulin and insulin-like growth factors I and II (IGF-I and IFG-II).
The receptor monomers also assemble as heterodimers, the primary ligand-binding
sites of which each comprise the first leucine-rich repeat domain (L1) of one
receptor type and an α-chain C-terminal segment (αCT) of the second receptor
type. We present here crystal structures of IGF-I bound to such a hybrid primary
binding site and of a ligand-free version of an IR αCT peptide bound to an IR
L1 plus cysteine-rich domain construct (IR310.T). These structures, refined at
3.0-Å resolution, prove congruent to respective existing structures of
insulin-complexed IR310.T and the intact apo-IR ectodomain. As such, they
provide key missing links in the emerging, but sparse, repertoire of structures
defining the receptor family.
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