PDBsum entry 4xmb

Protein binding

PDB id: 4xmb

Contents

Protein chain

286 a.a.

Ligands

41P

Waters ×143

PDB id:

4xmb

Name:

Protein binding

Title:

Crystal structure of 2,2'-(naphthalene-1,4-diylbis(((4-methoxyphenyl) sulfonyl)azanediyl))diacetamide bound to human keap1 kelch domain

Structure:

Kelch-like ech-associated protein 1. Chain: a. Fragment: kelch domain (unp residues 321-609). Synonym: cytosolic inhibitor of nrf2, inrf2, kelch-like protein 19, keap1. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: keap1, inrf2, kiaa0132, klhl19. Expressed in: escherichia coli. Expression_system_taxid: 562

Resolution:

2.43Å R-factor: 0.177 R-free: 0.229

Authors:

J.P.Luciano,A.F.Ryuzoji,A.D.Mesecar

Key ref:

A.D.Jain et al. (2015). Probing the structural requirements of non-electrophilic naphthalene-based Nrf2 activators. Eur J Med Chem, 103, 252-268. PubMed id: 26363505 DOI: 10.1016/j.ejmech.2015.08.049

Date:

14-Jan-15 Release date: 30-Sep-15

Protein chain

Q14145  (KEAP1_HUMAN) -  Kelch-like ECH-associated protein 1 from Homo sapiens

Seq: 624 a.a.

Struc: 286 a.a.

Enzyme reactions

• Enzyme class: E.C.?

DOI no: 10.1016/j.ejmech.2015.08.049

Eur J Med Chem 103:252-268 (2015)

PubMed id: 26363505

Probing the structural requirements of non-electrophilic naphthalene-based Nrf2 activators.

A.D.Jain, H.Potteti, B.G.Richardson, L.Kingsley, J.P.Luciano, A.F.Ryuzoji, H.Lee, A.Krunic, A.D.Mesecar, S.P.Reddy, T.W.Moore.

ABSTRACT

No abstract given.