PDBsum entry 4xi2

Transferase

PDB id: 4xi2

Contents

Protein chain

421 a.a.

Metals

_AU ×2

PDB id:

4xi2

Name:

Transferase

Title:

Crystal structure of an auto-inhibited form of bruton's tryrosine kinase

Structure:

Tyrosine-protein kinase btk. Chain: a. Fragment: unp residues 214-659. Synonym: agammaglobulinemia tyrosine kinase,atk,b-cell progenitor kinase,bpk,bruton tyrosine kinase,kinase emb. Engineered: yes

Source:

Mus musculus. Mouse. Organism_taxid: 10090. Gene: btk, bpk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.

Resolution:

2.60Å R-factor: 0.231 R-free: 0.248

Authors:

E.M.Vogan,S.C.Harrison

Key ref:

Q.Wang et al. (2015). Autoinhibition of Bruton's tyrosine kinase (Btk) and activation by soluble inositol hexakisphosphate. Elife, 4, . PubMed id: 25699547 DOI: 10.7554/eLife.06074

Date:

06-Jan-15 Release date: 25-Feb-15

Protein chain

P35991  (BTK_MOUSE) -  Tyrosine-protein kinase BTK from Mus musculus

Seq: 659 a.a.

Struc: 421 a.a.

Enzyme reactions

• Enzyme class: E.C.2.7.10.2 - non-specific protein-tyrosine kinase.
• Reaction: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H⁺

Molecule diagrams generated from .mol files obtained from the KEGG ftp site

Added reference

DOI no: 10.7554/eLife.06074

Elife 4: (2015)

PubMed id: 25699547

Autoinhibition of Bruton's tyrosine kinase (Btk) and activation by soluble inositol hexakisphosphate.

Q.Wang, E.M.Vogan, L.M.Nocka, C.E.Rosen, J.A.Zorn, S.C.Harrison, J.Kuriyan.

ABSTRACT

No abstract given.