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PDBsum entry 4xi0
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Protein binding
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PDB id
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4xi0
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References listed in PDB file
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Key reference
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Title
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Mama as a model protein for structure-Based insight into the evolutionary origins of magnetotactic bacteria.
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Authors
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N.Zeytuni,
S.Cronin,
C.T.Lefèvre,
P.Arnoux,
D.Baran,
Z.Shtein,
G.Davidov,
R.Zarivach.
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Ref.
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Plos One, 2015,
10,
e0130394.
[DOI no: ]
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PubMed id
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Abstract
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MamA is a highly conserved protein found in magnetotactic bacteria (MTB), a
diverse group of prokaryotes capable of navigating according to magnetic fields
- an ability known as magnetotaxis. Questions surround the acquisition of this
magnetic navigation ability; namely, whether it arose through horizontal or
vertical gene transfer. Though its exact function is unknown, MamA surrounds the
magnetosome, the magnetic organelle embedding a biomineralised nanoparticle and
responsible for magnetotaxis. Several structures for MamA from a variety of
species have been determined and show a high degree of structural similarity. By
determining the structure of MamA from Desulfovibrio magneticus RS-1 using X-ray
crystallography, we have opened up the structure-sequence landscape. As such,
this allows us to perform structural- and phylogenetic-based analyses using a
variety of previously determined MamA from a diverse range of MTB species across
various phylogenetic groups. We found that MamA has remained remarkably constant
throughout evolution with minimal change between different taxa despite sequence
variations. These findings, coupled with the generation of phylogenetic trees
using both amino acid sequences and 16S rRNA, indicate that magnetotaxis likely
did not spread via horizontal gene transfer and instead has a significantly
earlier, primordial origin.
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