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UniProt functional annotation for Q24168 | ||
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| UniProt code: Q24168. |
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| Organism: | |
Drosophila melanogaster (Fruit fly). |
| Taxonomy: | |
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora. |
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| Function: | |
Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. {ECO:0000269|PubMed:11137005}. |
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| Subunit: | |
ORC is composed of six subunits. Interacts with Mcm10. {ECO:0000269|PubMed:12808023}. |
| Subcellular location: | |
Nucleus {ECO:0000269|PubMed:11137005}. Chromosome {ECO:0000269|PubMed:11137005}. Chromosome, centromere {ECO:0000269|PubMed:11137005}. Note=Centromeres of metaphase and anaphase chromosomes of early syncytial embryos. Later in development, found in pericentric regions of late anaphase and telophase chromosomes. |
| Disruption phenotype: | |
Cause death late in larval development, with defects in cell-cycle progression and chromosome condensation in mitosis. {ECO:0000269|PubMed:11137005}. |
| Similarity: | |
Belongs to the ORC2 family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.