PDBsum entry 4xg8

Transferase/transferase inhibitor

PDB id: 4xg8

Contents

Protein chains

258 a.a.

Ligands

X8G ×2

Waters ×32

PDB id:

4xg8

Name:

Transferase/transferase inhibitor

Title:

Crystal structure of an inhibitor-bound syk

Structure:

Tyrosine-protein kinase syk. Chain: a, c. Fragment: protein kinase domain, residues 356-635. Synonym: spleen tyrosine kinase,p72-syk. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: syk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.

Resolution:

2.40Å R-factor: 0.249 R-free: 0.275

Authors:

S.J.Lee,J.Choi,B.G.Han,H.Song,J.S.Koh,B.I.Lee

Key ref:

S.J.Lee et al. (2016). Crystal structures of spleen tyrosine kinase in complex with novel inhibitors: structural insights for design of anticancer drugs. Febs J, 283, 3613-3625. PubMed id: 27504936 DOI: 10.1111/febs.13831

Date:

30-Dec-14 Release date: 30-Dec-15

Protein chains

P43405  (KSYK_HUMAN) -  Tyrosine-protein kinase SYK from Homo sapiens

Seq: 635 a.a.

Struc: 258 a.a.

Enzyme reactions

• Enzyme class: E.C.2.7.10.2 - non-specific protein-tyrosine kinase.
• Reaction: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H⁺

Molecule diagrams generated from .mol files obtained from the KEGG ftp site

Added reference

DOI no: 10.1111/febs.13831

Febs J 283:3613-3625 (2016)

PubMed id: 27504936

Crystal structures of spleen tyrosine kinase in complex with novel inhibitors: structural insights for design of anticancer drugs.

S.J.Lee, J.S.Choi, B.G.Han, H.S.Kim, H.J.Song, J.Lee, S.Nam, S.H.Goh, J.H.Kim, J.S.Koh, B.I.Lee.

ABSTRACT

No abstract given.