PDBsum entry 4wrg

Transferase

PDB id: 4wrg

Contents

Protein chain

290 a.a.

Ligands

MES

Metals

_NA

Waters ×111

PDB id:

4wrg

Name:

Transferase

Title:

1.9 angstrom structure of egfr kinase domain

Structure:

Epidermal growth factor receptor. Chain: a. Synonym: proto-oncogenE C-erbb-1,receptor tyrosine-protein kinase erbb-1. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108

Resolution:

1.90Å R-factor: 0.198 R-free: 0.212

Authors:

C.J.Squire,Y.Yosaatmadja,J.U.Flanagan,M.Mckeage

Key ref:

C.J.Squire et al. 1.9 angstrom structure of egfr kinase domain. To be published, .

Date:

23-Oct-14 Release date: 05-Nov-14

Protein chain

P00533  (EGFR_HUMAN) -  Epidermal growth factor receptor from Homo sapiens

Seq: 1210 a.a.

Struc: 290 a.a.*

* PDB and UniProt seqs differ at 3 residue positions (black crosses)

Enzyme reactions

• Enzyme class: E.C.2.7.10.1 - receptor protein-tyrosine kinase.
• Reaction: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H⁺

Molecule diagrams generated from .mol files obtained from the KEGG ftp site