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UniProt functional annotation for P08427 | ||
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| UniProt code: P08427. |
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| Organism: | |
Rattus norvegicus (Rat). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus. |
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| Function: | |
In presence of calcium ions, it binds to surfactant phospholipids and contributes to lower the surface tension at the air- liquid interface in the alveoli of the mammalian lung and is essential for normal respiration. Enhances the expression of MYO18A/SP-R210 on alveolar macrophages. {ECO:0000250|UniProtKB:P35242}. |
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| Subunit: | |
Oligomeric complex of 6 set of homotrimers. {ECO:0000269|PubMed:12913002}. |
| Subcellular location: | |
Secreted, extracellular space, extracellular matrix. Secreted, extracellular space, surface film. |
| Miscellaneous: | |
Pulmonary surfactant consists of 90% lipid and 10% protein. There are 4 surfactant-associated proteins: 2 collagenous, carbohydrate-binding glycoproteins (SP-A and SP-D) and 2 small hydrophobic proteins (SP-B and SP-C). |
| Similarity: | |
Belongs to the SFTPA family. {ECO:0000305}. |
| Sequence caution: | |
Sequence=AAA41972.1; Type=Erroneous initiation; Evidence={ECO:0000305}; |
Annotations taken from UniProtKB at the EBI.