 |
PDBsum entry 4woc
|
|
|
|
References listed in PDB file
|
 |
|
Key reference
|
|
|
Title
|
|
Precise manipulation and patterning of protein crystals for macromolecular crystallography using surface acoustic waves.
|
|
|
Authors
|
|
F.Guo,
W.Zhou,
P.Li,
Z.Mao,
N.H.Yennawar,
J.B.French,
T.J.Huang.
|
|
|
Ref.
|
|
Small, 2015,
11,
2733-2737.
[DOI no: ]
|
|
|
PubMed id
|
|
|
|
|
|
Abstract
|
|
|
Advances in modern X-ray sources and detector technology have made it possible
for crystallographers to collect usable data on crystals of only a few
micrometers or less in size. Despite these developments, sample handling
techniques have significantly lagged behind and often prevent the full
realization of current beamline capabilities. In order to address this
shortcoming, a surface acoustic wave-based method for manipulating and
patterning crystals is developed. This method, which does not damage the fragile
protein crystals, can precisely manipulate and pattern micrometer and
submicrometer-sized crystals for data collection and screening. The technique is
robust, inexpensive, and easy to implement. This method not only promises to
significantly increase efficiency and throughput of both conventional and serial
crystallography experiments, but will also make it possible to collect data on
samples that were previously intractable.
|
|
|
|
|
|
|
