PDBsum entry 4wkq

Transferase/transferase inhibitor

PDB id: 4wkq

Contents

Protein chain

297 a.a.

Ligands

IRE

MES

Metals

_NA

Waters ×121

PDB id:

4wkq

Name:

Transferase/transferase inhibitor

Title:

1.85 angstrom structure of egfr kinase domain with gefitinib

Structure:

Epidermal growth factor receptor. Chain: a. Fragment: unp residues 696-1022. Synonym: proto-oncogenE C-erbb-1,receptor tyrosine-protein kinase erbb-1. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Cell_line: sf9. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.

Resolution:

1.85Å R-factor: 0.196 R-free: 0.225

Authors:

Y.Yosaatmadja,C.J.Squire

Key ref:

Y.Yosaatmadja et al. 1.85 angstrom structure of egfr kinase domain with ge. To be published, .

Date:

03-Oct-14 Release date: 05-Nov-14

Protein chain

P00533  (EGFR_HUMAN) -  Epidermal growth factor receptor from Homo sapiens

Seq: 1210 a.a.

Struc: 297 a.a.*

* PDB and UniProt seqs differ at 3 residue positions (black crosses)

Enzyme reactions

• Enzyme class: E.C.2.7.10.1 - receptor protein-tyrosine kinase.
• Reaction: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H⁺

Molecule diagrams generated from .mol files obtained from the KEGG ftp site