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UniProt functional annotation for P25382 | ||
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| UniProt code: P25382. |
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| Organism: | |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). |
| Taxonomy: | |
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. |
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| Function: | |
Involved in ribosome biogenesis. Required for processing and efficient intra-nuclear transport of pre-60S ribosomal subunits. Interacts with the AAA-ATPase Midasin (MDN1/REA1), which is essential for the ATP-dependent dissociation of a group of nonribosomal factors from the pre-60S particle. {ECO:0000269|PubMed:16221974, ECO:0000269|PubMed:19737519, ECO:0000269|PubMed:20542003}. |
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| Subunit: | |
Associates with the pre-60S ribosomal particle (PubMed:16702403, PubMed:18658244, PubMed:19737519). Interacts (via WD repeats) with uL18 (RPL5) (PubMed:25404745). Interacts (via UBL domain) with MDN1 (via VWFA/MIDAS domain) (PubMed:19737519, PubMed:20542003). Interacts (via WD repeats) with NSA2 (PubMed:25404745). {ECO:0000269|PubMed:16702403, ECO:0000269|PubMed:18658244, ECO:0000269|PubMed:19737519, ECO:0000269|PubMed:20542003, ECO:0000269|PubMed:25404745}. |
| Subcellular location: | |
Nucleus, nucleolus {ECO:0000269|PubMed:16221974}. |
| Similarity: | |
Belongs to the NLE1/RSA4 family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.