PDBsum entry 4wi9

Immune system

PDB id: 4wi9

Contents

Protein chains

208 a.a.

Ligands

NAG-FUC

NAG-BMA-MAN-NAG-MAN-NAG

NAG-NAG-BMA-MAN-NAG-MAN-NAG-FUC

Waters ×30

PDB id:

4wi9

Name:

Immune system

Title:

Structural mapping of the human igg1 binding site for fcrn: hu3s193 fc mutation i253a/h310a

Structure:

Ig gamma-1 chain c region. Chain: a, b. Fragment: unp residues 120-327. Engineered: yes. Mutation: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: ighg1. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: 293f

Resolution:

2.65Å R-factor: 0.213 R-free: 0.274

Authors:

W.Farrugia,I.J.G.Burvenich,A.M.Scott,P.A.Ramsland

Key ref:

I.J.G.Burvenich et al. Structural and functional mapping of human igg1 bindi for fcrn in vivo using human fcrn transgenic mice. To be published, .

Date:

25-Sep-14 Release date: 30-Sep-15

Protein chains

P01857  (IGHG1_HUMAN) -  Immunoglobulin heavy constant gamma 1 from Homo sapiens

Seq: 399 a.a.

Struc: 208 a.a.*

* PDB and UniProt seqs differ at 2 residue positions (black crosses)