PDBsum entry 4whu

Transferase/transferase inhibitor

PDB id

4whu

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Contents

			Protein chain

					119 a.a.

			Ligands

					3OT

			Waters ×13

PDB id:

4whu

Links

Name:

Transferase/transferase inhibitor

Title:

Bromo domain of creb binding protein

Structure:

Creb-binding protein. Chain: a. Fragment: unp residues 1081-1197. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: crebbp, cbp. Expressed in: escherichia coli 'bl21-gold(de3)plyss ag'. Expression_system_taxid: 866768

Resolution:

2.11Å

R-factor:

0.210

R-free:

0.261

Authors:

S.Liu

Key ref:

E.C.Hett et al. Direct photocapture of bromodomains using tropolone c probes. To be published, .

Date:

23-Sep-14

Release date:

28-Oct-15

PROCHECK

	Headers

	References

Protein chain

Q92793 (CBP_HUMAN) - CREB-binding protein from Homo sapiens

Seq: Struc:

Seq: Struc:

Seq: Struc:

Seq: Struc:

Seq: Struc:					2442 a.a. 119 a.a.*

Key:

PfamA domain

Secondary structure

CATH domain

* PDB and UniProt seqs differ at 2 residue positions (black crosses)



		Enzyme reactions

Enzyme class 1:

E.C.2.3.1.- - ?????

[IntEnz] [ExPASy] [KEGG] [BRENDA]

Enzyme class 2:

E.C.2.3.1.48 - histone acetyltransferase.

[IntEnz] [ExPASy] [KEGG] [BRENDA]

Reaction:

L-lysyl-[protein] + acetyl-CoA = N₆-acetyl-L-lysyl-[protein] + CoA + H⁺

L-lysyl-[protein]	+	acetyl-CoA	=	N(6)-acetyl-L-lysyl-[protein]	+	CoA	+	H(+)

Note, where more than one E.C. class is given (as above), each may correspond to a different protein domain or, in the case of polyprotein precursors, to a different mature protein.

Molecule diagrams generated from .mol files obtained from the KEGG ftp site