UniProt functional annotation for P40199



	UniProt functional annotation for P40199

UniProt code: P40199.

Organism: Homo sapiens (Human).

Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.

Function: Cell surface glycoprotein that plays a role in cell adhesion and tumor progression (PubMed:2803308, PubMed:2022629, PubMed:1378450, PubMed:8776764, PubMed:11590190, PubMed:10910050, PubMed:14724575, PubMed:16204051). Intercellular adhesion occurs in a calcium- and fibronectin-independent manner (PubMed:2022629, PubMed:16204051). Mediates homophilic and heterophilic cell adhesion with other carcinoembryonic antigen-related cell adhesion molecules, such as CEACAM5 and CEACAM8 (PubMed:2803308, PubMed:2022629, PubMed:8776764, PubMed:11590190, PubMed:16204051). Heterophilic interaction with CEACAM8 occurs in activated neutrophils (PubMed:8776764). Plays a role in neutrophil adhesion to cytokine-activated endothelial cells (PubMed:1378450). Plays a role as an oncogene by promoting tumor progression; positively regulates cell migration, cell adhesion to endothelial cells and cell invasion (PubMed:16204051). Also involved in the metastatic cascade process by inducing gain resistance to anoikis of pancreatic adenocarcinoma and colorectal carcinoma cells (PubMed:10910050, PubMed:14724575). {ECO:0000269|PubMed:10910050, ECO:0000269|PubMed:11590190, ECO:0000269|PubMed:1378450, ECO:0000269|PubMed:14724575, ECO:0000269|PubMed:16204051, ECO:0000269|PubMed:2022629, ECO:0000269|PubMed:2803308, ECO:0000269|PubMed:8776764}.

Subunit: Homodimer; homodimerizes via its Ig-like V-type domain. Heterodimer with CEACAM8; heterodimerizes via its Ig-like V-type domain. {ECO:0000269|PubMed:26483485}.

Subcellular location: Cell membrane; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:2317824}. Apical cell membrane {ECO:0000269|PubMed:10436421}. Cell surface {ECO:0000269|PubMed:1378450, ECO:0000269|PubMed:16204051, ECO:0000269|PubMed:2317824, ECO:0000269|PubMed:8776764, ECO:0000305|PubMed:2803308}. Note=Localized to the apical glycocalyx surface. {ECO:0000269|PubMed:10436421}.

Tissue specificity: Expressed in neutrophils (PubMed:1378450). Expressed in columnar epithelial and goblet cells of the colon (PubMed:10436421). Expressed in numerous tumor cell lines (at protein level) (PubMed:16204051). {ECO:0000269|PubMed:10436421, ECO:0000269|PubMed:1378450, ECO:0000269|PubMed:16204051}.

Induction: Up-regulated in anoikis-resistant pancreatic adenocarcinoma cells (at protein level). {ECO:0000269|PubMed:14724575}.

Domain: The extracellular N-terminus Ig-like V-type domain is necessary for homophilic and heterophilic intercellular adhesion. {ECO:0000269|PubMed:11590190, ECO:0000269|PubMed:2022629, ECO:0000269|PubMed:8776764}.

Ptm: Glycosylated. {ECO:0000269|PubMed:26483485}.

Similarity: Belongs to the immunoglobulin superfamily. CEA family. {ECO:0000305}.

Annotations taken from UniProtKB at the EBI.


Organism:		Homo sapiens (Human).
Taxonomy:		Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.



Function:		Cell surface glycoprotein that plays a role in cell adhesion and tumor progression (PubMed:2803308, PubMed:2022629, PubMed:1378450, PubMed:8776764, PubMed:11590190, PubMed:10910050, PubMed:14724575, PubMed:16204051). Intercellular adhesion occurs in a calcium- and fibronectin-independent manner (PubMed:2022629, PubMed:16204051). Mediates homophilic and heterophilic cell adhesion with other carcinoembryonic antigen-related cell adhesion molecules, such as CEACAM5 and CEACAM8 (PubMed:2803308, PubMed:2022629, PubMed:8776764, PubMed:11590190, PubMed:16204051). Heterophilic interaction with CEACAM8 occurs in activated neutrophils (PubMed:8776764). Plays a role in neutrophil adhesion to cytokine-activated endothelial cells (PubMed:1378450). Plays a role as an oncogene by promoting tumor progression; positively regulates cell migration, cell adhesion to endothelial cells and cell invasion (PubMed:16204051). Also involved in the metastatic cascade process by inducing gain resistance to anoikis of pancreatic adenocarcinoma and colorectal carcinoma cells (PubMed:10910050, PubMed:14724575). {ECO:0000269\|PubMed:10910050, ECO:0000269\|PubMed:11590190, ECO:0000269\|PubMed:1378450, ECO:0000269\|PubMed:14724575, ECO:0000269\|PubMed:16204051, ECO:0000269\|PubMed:2022629, ECO:0000269\|PubMed:2803308, ECO:0000269\|PubMed:8776764}.


Subunit:		Homodimer; homodimerizes via its Ig-like V-type domain. Heterodimer with CEACAM8; heterodimerizes via its Ig-like V-type domain. {ECO:0000269\|PubMed:26483485}.
Subcellular location:		Cell membrane; Lipid-anchor, GPI-anchor {ECO:0000269\|PubMed:2317824}. Apical cell membrane {ECO:0000269\|PubMed:10436421}. Cell surface {ECO:0000269\|PubMed:1378450, ECO:0000269\|PubMed:16204051, ECO:0000269\|PubMed:2317824, ECO:0000269\|PubMed:8776764, ECO:0000305\|PubMed:2803308}. Note=Localized to the apical glycocalyx surface. {ECO:0000269\|PubMed:10436421}.
Tissue specificity:		Expressed in neutrophils (PubMed:1378450). Expressed in columnar epithelial and goblet cells of the colon (PubMed:10436421). Expressed in numerous tumor cell lines (at protein level) (PubMed:16204051). {ECO:0000269\|PubMed:10436421, ECO:0000269\|PubMed:1378450, ECO:0000269\|PubMed:16204051}.
Induction:		Up-regulated in anoikis-resistant pancreatic adenocarcinoma cells (at protein level). {ECO:0000269\|PubMed:14724575}.
Domain:		The extracellular N-terminus Ig-like V-type domain is necessary for homophilic and heterophilic intercellular adhesion. {ECO:0000269\|PubMed:11590190, ECO:0000269\|PubMed:2022629, ECO:0000269\|PubMed:8776764}.
Ptm:		Glycosylated. {ECO:0000269\|PubMed:26483485}.
Similarity:		Belongs to the immunoglobulin superfamily. CEA family. {ECO:0000305}.