PDBsum entry 4wg4

Transferase/transferase inhibitor

PDB id: 4wg4

Contents

Protein chain

454 a.a.

Ligands

UWB

Waters ×48

PDB id:

4wg4

Name:

Transferase/transferase inhibitor

Title:

Calcium-dependent protein kinase 1 from toxoplasma gondii (tgcdpk1) in complex with inhibitor uw1613

Structure:

Calmodulin-domain protein kinase 1. Chain: a. Fragment: unp residues 30-507. Engineered: yes

Source:

Toxoplasma gondii. Organism_taxid: 5811. Gene: cdpk1. Expressed in: escherichia coli. Expression_system_taxid: 469008.

Resolution:

2.30Å R-factor: 0.208 R-free: 0.248

Authors:

E.A.Merritt

Key ref:

E.A.Merritt Calcium-Dependent protein kinase 1 from toxoplasma go (tgcdpk1) in complex with inhibitor uw1613. To be published, .

Date:

17-Sep-14 Release date: 15-Oct-14

Protein chain

Q9BJF5  (Q9BJF5_TOXGO) -  Calmodulin-domain protein kinase 1 from Toxoplasma gondii

Seq: 507 a.a.

Struc: 454 a.a.

Enzyme reactions

• Enzyme class: E.C.2.7.11.17 - calcium/calmodulin-dependent protein kinase.
• Reaction:
  1. L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H⁺
  2. L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H⁺
• Cofactor: Ca(2+)

Molecule diagrams generated from .mol files obtained from the KEGG ftp site