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UniProt functional annotation for P12314 | ||
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| UniProt code: P12314. |
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| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
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| Function: | |
High affinity receptor for the Fc region of immunoglobulins gamma. Functions in both innate and adaptive immune responses. {ECO:0000269|PubMed:10397749, ECO:0000269|PubMed:10514529, ECO:0000269|PubMed:21965667, ECO:0000269|PubMed:8611682, ECO:0000269|PubMed:9881690}. |
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| Subunit: | |
Interacts with FCERG1; forms a functional signaling complex. Interacts with FLNA; prevents FCGR1A degradation. Interacts with EPB41L2, LAT and PPL. Interacts with HCK and LYN. {ECO:0000269|PubMed:10514529, ECO:0000269|PubMed:10781611, ECO:0000269|PubMed:15229321, ECO:0000269|PubMed:18023480, ECO:0000269|PubMed:18322202, ECO:0000269|PubMed:8064233, ECO:0000269|PubMed:8611682}. |
| Subcellular location: | |
Cell membrane {ECO:0000269|PubMed:12756162, ECO:0000269|PubMed:8611682}; Single-pass type I membrane protein {ECO:0000269|PubMed:12756162, ECO:0000269|PubMed:8611682}. Note=Stabilized at the cell membrane through interaction with FCER1G. |
| Tissue specificity: | |
Monocyte/macrophage specific. |
| Ptm: | |
Phosphorylated on serine residues. {ECO:0000250}. |
| Similarity: | |
Belongs to the immunoglobulin superfamily. FCGR1 family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.