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UniProt functional annotation for Q07915 | ||
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| UniProt code: Q07915. |
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| Organism: | |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). |
| Taxonomy: | |
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. |
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| Function: | |
Involved in the biogenesis of the 60S ribosomal subunit (PubMed:12808088, PubMed:23185031). Ensures the docking of NOG1 to pre- 60S ribosomal particles (PubMed:12808088). Activates and recruits ATPase AFG2 to cytoplasmic pre-60S ribosomal particles (PubMed:23185031). {ECO:0000269|PubMed:12808088, ECO:0000269|PubMed:23185031}. |
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| Subunit: | |
Associated with nucleolar and cytoplasmic pre-60S particles (PubMed:12808088). At the end of biogenesis it dissociates from cytoplasmic pre-60S particles and is likely to be exchanged for its ribosomal homolog, RPL24 (PubMed:12808088, PubMed:23185031). Interacts (via C-terminus) with AFG2 (hexameric form); the interaction is direct, recruits AFG2 to pre-60S ribosomal particles and promotes AFG2 ATPase activity and RLP24 release from pre-60S ribosomal particles (PubMed:23185031). Interacts with NOG1; the interaction is direct (PubMed:12808088). {ECO:0000269|PubMed:12808088, ECO:0000269|PubMed:23185031}. |
| Subcellular location: | |
Cytoplasm {ECO:0000269|PubMed:12808088}. Nucleus {ECO:0000269|PubMed:12808088}. Note=Shuttles between the nucleus and the cytoplasm. {ECO:0000269|PubMed:12808088}. |
| Similarity: | |
Belongs to the eukaryotic ribosomal protein eL24 family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.