 |
PDBsum entry 4uyd
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Transcription
|
PDB id
|
|
|
|
4uyd
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PDB id:
|
|
|
|
| Name: |
|
Transcription
|
|
|
Title:
|
|
N-terminal bromodomain of human brd4 with 1,3-dimethyl-2-oxo-2,3- dihydro-1h-1,3-benzodiazole-5-carboxamide
|
|
Structure:
|
|
Bromodomain-containing protein 4. Chain: a. Fragment: n-terminal bromodomain, unp residues 44-183. Synonym: protein hunk1. Engineered: yes
|
|
Source:
|
|
Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
Resolution:
|
|
|
1.37Å
|
R-factor:
|
0.175
|
R-free:
|
0.188
|
|
|
Authors:
|
|
C.Chung,P.Bamborough,E.Demont
|
|
Key ref:
|
|
E.H.Demont
et al.
(2014).
1,3-Dimethyl Benzimidazolones Are Potent, Selective Inhibitors of the BRPF1 Bromodomain.
Acs Med Chem Lett,
5,
1190-1195.
PubMed id:
DOI:
|
|
|
Date:
|
|
|
30-Aug-14
|
Release date:
|
17-Sep-14
|
|
|
|
|
|
|
PROCHECK
|
|
|
|
|
|
Headers
|
|
|
|
References
|
|
|
|
|
|
|
|
O60885
(BRD4_HUMAN) -
Bromodomain-containing protein 4 from Homo sapiens
|
|
|
|
Seq:
Struc:
|
|
|
|
1362 a.a.
127 a.a.*
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Key: |
|
 |
Secondary structure |
|
 |
CATH domain |
|
|
*
PDB and UniProt seqs differ
at 1 residue position (black
cross)
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
 |
|
|
|
|
|
|
| |
|
DOI no:
|
Acs Med Chem Lett
5:1190-1195
(2014)
|
|
PubMed id:
|
|
|
|
|
|
| |
|
1,3-Dimethyl Benzimidazolones Are Potent, Selective Inhibitors of the BRPF1 Bromodomain.
|
|
E.H.Demont,
P.Bamborough,
C.W.Chung,
P.D.Craggs,
D.Fallon,
L.J.Gordon,
P.Grandi,
C.I.Hobbs,
J.Hussain,
E.J.Jones,
A.Le Gall,
A.M.Michon,
D.J.Mitchell,
R.K.Prinjha,
A.D.Roberts,
R.J.Sheppard,
R.J.Watson.
|
|
|
|
|
| |
ABSTRACT
|
|
|
|
| |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
 |
 |
 |
|
Links
