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PDBsum entry 4uxn
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protein ligands Protein-protein interface(s) links
Oxidoreductase PDB id
4uxn

 

 

 

 

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Contents
Protein chains
666 a.a.
133 a.a.
Ligands
FAD-M8A
PDB id:
4uxn
Name: Oxidoreductase
Title: Lsd1(kdm1a)-corest in complex with z-pro derivative of mc2580
Structure: Lysine-specific histone demethylase 1a. Chain: a. Synonym: braf35-hdac complex protein bhc110, flavin-containing amine oxidase domain-containing protein 2. Engineered: yes. Rest corepressor 1. Chain: b. Synonym: protein corest. Engineered: yes
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Resolution:
2.85Å     R-factor:   0.206     R-free:   0.215
Authors: V.Rodriguez,S.Valente,G.Stazi,A.Lucidi,C.Mercurio,P.Vianello, G.Ciossani,A.Mattevi,O.A.Botrugno,P.Dessanti,S.Minucci,M.Varasi, A.Mai
Key ref: V.Rodriguez et al. Pyrrole- And indole-Containing tranylcypromine deriva as novel lysine-Specific demethylase 1 inhibitors act cancer cells. Chemmedchem, .
Date:
27-Aug-14     Release date:   25-Feb-15    
PROCHECK
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 Headers
 References

Protein chain
O60341  (KDM1A_HUMAN) -  Lysine-specific histone demethylase 1A from Homo sapiens
Seq:
Struc: 		 
Seq:
Struc: 		852 a.a.
666 a.a.
Protein chain
Q9UKL0  (RCOR1_HUMAN) -  REST corepressor 1 from Homo sapiens
Seq:
Struc: 		485 a.a.
133 a.a.
Key:    Secondary structure  CATH domain

 Enzyme reactions 
   Enzyme class: Chain A: E.C.1.14.99.66  - [histone-H3]-N(6),N(6)-dimethyl-L-lysine(4) FAD-dependent demethylase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: N6,N6-dimethyl-L-lysyl4-[histone H3] + 2 A + 2 H2O = L-lysyl4- [histone H3] + 2 formaldehyde + 2 AH2
N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3]
 + 2 × A
 + 2 × H2O
 = L-lysyl(4)- [histone H3]
 + 2 × formaldehyde
 + 2 × AH2
Molecule diagrams generated from .mol files obtained from the KEGG ftp site

 

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