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PDBsum entry 4uww
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Structural protein
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PDB id
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4uww
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References listed in PDB file
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Key reference
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Title
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Structure of struthiocalcin-1, An intramineral protein from struthio camelus eggshell, In two crystal forms.
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Authors
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R.R.Ruiz-Arellano,
F.J.Medrano,
A.Moreno,
A.Romero.
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Ref.
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Acta Crystallogr D Biol Crystallogr, 2015,
71,
809-818.
[DOI no: ]
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PubMed id
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Abstract
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Biomineralization is the process by which living organisms produce minerals. One
remarkable example is the formation of eggshells in birds. Struthiocalcins
present in the ostrich (Struthio camellus) eggshell matrix act as biosensors of
calcite growth during eggshell formation. Here, the crystal structure of
struthiocalcin-1 (SCA-1) is reported in two different crystal forms. The
structure is a compact single domain with an α/β fold characteristic of the
C-type lectin family. In contrast to the related avian ovocleidin OC17, the
electrostatic potential on the molecular surface is dominated by an acidic
patch. Scanning electron microscopy combined with Raman spectroscopy indicates
that these intramineral proteins (SCA-1 and SCA-2) induce calcium carbonate
precipitation, leading to the formation of a stable form of calcite in the
mature eggshell. Finally, the implications of these two intramineral proteins
SCA-1 and SCA-2 in the nucleation of calcite during the formation of eggshells
in ratite birds are discussed.
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