UniProt functional annotation for Q6NW40



	UniProt functional annotation for Q6NW40

UniProt code: Q6NW40.

Organism: Homo sapiens (Human).

Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.

Function: Member of the repulsive guidance molecule (RGM) family that contributes to the patterning of the developing nervous system (By similarity). Acts as a bone morphogenetic protein (BMP) coreceptor that potentiates BMP signaling (By similarity). Promotes neuronal adhesion (By similarity). May inhibit neurite outgrowth. {ECO:0000250|UniProtKB:Q7TQ33, ECO:0000269|PubMed:19324014}.

Subunit: Homooligomer (By similarity). Interacts with DRGX (By similarity). Interacts with BMP2 and BMP4 (By similarity). Interacts with the BMP type I receptors ACVR1, BMPR1A and BMPR1B and with the BMP type II receptor ACVR2B (By similarity). The functional complex with its receptor NEO1/neogenin appears to be a heterotetramer with a 2:2 stoichiometry, RGM molecules acting as staples that bring two NEO1 receptors together without interacting themselves, this arrangement leads to activation of downstream signaling via RhoA. {ECO:0000250|UniProtKB:Q7TQ33, ECO:0000269|PubMed:23744777}.

Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q7TQ33}; Lipid-anchor, GPI-anchor {ECO:0000250|UniProtKB:Q7TQ33}. Membrane raft {ECO:0000250|UniProtKB:Q7TQ33}.

Ptm: GPI-anchored. {ECO:0000250|UniProtKB:Q7TQ33}.

Ptm: Autocatalytically cleaved at low pH; the two chains remain linked via two disulfide bonds. {ECO:0000269|PubMed:23744777}.

Similarity: Belongs to the repulsive guidance molecule (RGM) family. {ECO:0000305}.

Sequence caution: Sequence=AAH67736.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305}; Sequence=BAC11268.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305};

Annotations taken from UniProtKB at the EBI.


Organism:		Homo sapiens (Human).
Taxonomy:		Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.



Function:		Member of the repulsive guidance molecule (RGM) family that contributes to the patterning of the developing nervous system (By similarity). Acts as a bone morphogenetic protein (BMP) coreceptor that potentiates BMP signaling (By similarity). Promotes neuronal adhesion (By similarity). May inhibit neurite outgrowth. {ECO:0000250\|UniProtKB:Q7TQ33, ECO:0000269\|PubMed:19324014}.


Subunit:		Homooligomer (By similarity). Interacts with DRGX (By similarity). Interacts with BMP2 and BMP4 (By similarity). Interacts with the BMP type I receptors ACVR1, BMPR1A and BMPR1B and with the BMP type II receptor ACVR2B (By similarity). The functional complex with its receptor NEO1/neogenin appears to be a heterotetramer with a 2:2 stoichiometry, RGM molecules acting as staples that bring two NEO1 receptors together without interacting themselves, this arrangement leads to activation of downstream signaling via RhoA. {ECO:0000250\|UniProtKB:Q7TQ33, ECO:0000269\|PubMed:23744777}.
Subcellular location:		Cell membrane {ECO:0000250\|UniProtKB:Q7TQ33}; Lipid-anchor, GPI-anchor {ECO:0000250\|UniProtKB:Q7TQ33}. Membrane raft {ECO:0000250\|UniProtKB:Q7TQ33}.
Ptm:		GPI-anchored. {ECO:0000250\|UniProtKB:Q7TQ33}.
Ptm:		Autocatalytically cleaved at low pH; the two chains remain linked via two disulfide bonds. {ECO:0000269\|PubMed:23744777}.
Similarity:		Belongs to the repulsive guidance molecule (RGM) family. {ECO:0000305}.
Sequence caution:		Sequence=AAH67736.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305}; Sequence=BAC11268.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305};