|
|
||
|
|
|
|
|
UniProt functional annotation for Q6P4R8 | ||
|
|
|
|
|
|
||
| UniProt code: Q6P4R8. |
|
||
| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
|
||
|
||
| Function: | |
Binds to the DNA consensus sequence 5'-GGGGAATCTCC-3'. {ECO:0000269|PubMed:18922472}. |
|
||
|
||
| Function: | |
Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. Modulates the deubiquitinase activity of UCHL5 in the INO80 complex. {ECO:0000269|PubMed:18922472}. |
|
||
| Subunit: | |
Component of the chromatin remodeling INO80 complex; specifically part of a complex module associated with the N-terminus of INO80. Interacts with UCHL5; NFRKB competes with ADRM1 for interaction with UCHL5. {ECO:0000269|PubMed:16230350, ECO:0000269|PubMed:18922472, ECO:0000269|PubMed:21303910}. |
| Subcellular location: | |
Nucleus {ECO:0000269|PubMed:18922472}. |
| Tissue specificity: | |
Expressed in thymus, brain, testes, spleen and liver. {ECO:0000269|PubMed:1777480}. |
| Domain: | |
NFRKB seems to be mostly disordered. The wing-helix like domain doesn't bind DNA. |
| Similarity: | |
Belongs to the NFRKB family. {ECO:0000305}. |
| Sequence caution: | |
Sequence=AAA17871.1; Type=Frameshift; Evidence={ECO:0000305}; |
Annotations taken from UniProtKB at the EBI.