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PDBsum entry 4udt
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Immune system
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PDB id
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4udt
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References listed in PDB file
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Key reference
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Title
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Structure of staphylococcal enterotoxin e in complex with tcr defines the role of tcr loop positioning in superantigen recognition.
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Authors
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K.E.Rödström,
P.Regenthal,
K.Lindkvist-Petersson.
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Ref.
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Plos One, 2015,
10,
e0131988.
[DOI no: ]
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PubMed id
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Abstract
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T cells are crucial players in cell-mediated immunity. The specificity of their
receptor, the T cell receptor (TCR), is central for the immune system to
distinguish foreign from host antigens. Superantigens are bacterial toxins
capable of inducing a toxic immune response by cross-linking the TCR and the
major histocompatibility complex (MHC) class II and circumventing the antigen
specificity. Here, we present the structure of staphylococcal enterotoxin E
(SEE) in complex with a human T cell receptor, as well as the unligated T cell
receptor structure. There are clear structural changes in the TCR loops upon
superantigen binding. In particular, the HV4 loop moves to circumvent steric
clashes upon complex formation. In addition, a predicted ternary model of SEE in
complex with both TCR and MHC class II displays intermolecular contacts between
the TCR α-chain and the MHC, suggesting that the TCR α-chain is of importance
for complex formation.
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