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UniProt functional annotation for Q04660 | ||
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| UniProt code: Q04660. |
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| Organism: | |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). |
| Taxonomy: | |
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. |
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| Function: | |
Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome. {ECO:0000255|HAMAP-Rule:MF_03027, ECO:0000269|PubMed:11522832, ECO:0000269|PubMed:18448671}. |
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| Subunit: | |
Component of the NOP7 complex, composed of ERB1, NOP7 and YTM1. The complex is held together by ERB1, which interacts with NOP7 via its N-terminal domain and with YTM1 via a high-affinity interaction between the seven-bladed beta-propeller domains of the 2 proteins. The NOP7 complex associates with the 66S pre-ribosome. Also interacts with NOG1. {ECO:0000255|HAMAP-Rule:MF_03027, ECO:0000269|PubMed:12110181, ECO:0000269|PubMed:16287855, ECO:0000269|PubMed:16888624}. |
| Subcellular location: | |
Nucleus, nucleolus {ECO:0000255|HAMAP- Rule:MF_03027, ECO:0000269|PubMed:18448671}. Nucleus, nucleoplasm {ECO:0000255|HAMAP-Rule:MF_03027, ECO:0000269|PubMed:18448671}. |
| Miscellaneous: | |
Present with 2680 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}. |
| Similarity: | |
Belongs to the WD repeat BOP1/ERB1 family. {ECO:0000255|HAMAP-Rule:MF_03027}. |
Annotations taken from UniProtKB at the EBI.