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UniProt functional annotation for P38339 | ||
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| UniProt code: P38339. |
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| Organism: | |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). |
| Taxonomy: | |
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. |
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| Function: | |
GTPase activating protein of RHO3 and RHO4. Acts in concert with MID2 in cell integrity, which is functionally linked to the PKC pathway. Involved in various stress responses. Required at low pH for activation of the PKC pathway. Important during mating response. {ECO:0000269|PubMed:10526184, ECO:0000269|PubMed:10590461, ECO:0000269|PubMed:11779787, ECO:0000269|PubMed:15922872, ECO:0000269|PubMed:16087742}. |
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| Subcellular location: | |
Cytoplasm {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:23454383}. Note=Bud and bud neck. During isotropic bud growth in the G1 and S phases, detected at the bud tip. During cytokinesis, undetectable at the bud tip and localized at the bud neck only. |
| Induction: | |
Induced by stress including low pH, heat shock and oxidative shock. Basal and acid-stressed expression level is regulated by transcription factors MSN2 and MSN4 as well as the HOG pathway. |
| Ptm: | |
Phosphorylated in vivo. In vitro, phosphorylated by IPL1. {ECO:0000269|PubMed:23454383}. |
| Miscellaneous: | |
Present with 1500 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}. |
| Miscellaneous: | |
Lack of RGD1 diminishes the PKC pathway activity. |
Annotations taken from UniProtKB at the EBI.