UniProt functional annotation for Q05322



	UniProt functional annotation for Q05322

UniProt code: Q05322.

Organism: Zaire ebolavirus (strain Mayinga-76) (ZEBOV) (Zaire Ebola virus).

Taxonomy: Viruses; Riboviria; Orthornavirae; Negarnaviricota; Haploviricotina; Monjiviricetes; Mononegavirales; Filoviridae; Ebolavirus.

Function: Prevents the establishment of cellular antiviral state by blocking the interferon-alpha/beta (IFN-alpha/beta) and IFN-gamma signaling pathways. Blocks the IFN-induced nuclear accumulation of host phosphorylated STAT1 by interacting with the STAT1-binding region of host importins. Alternatively interacts also directly with host STAT1 and may additionally inhibit its non-phosphorylated form. Plays a role in assembly of viral nucleocapsid and virion budding. May act as a minor matrix protein that plays a role in assembly of viral nucleocapsid and virion budding. {ECO:0000269|PubMed:12191476, ECO:0000269|PubMed:12525613, ECO:0000269|PubMed:15220407, ECO:0000269|PubMed:17928350, ECO:0000269|PubMed:25121748}.

Subunit: Interacts with host importins KPNA1, KPNA5 and KPNA6 (PubMed:17928350, PubMed:25121748,PubMed:27974555). Interacts with host STAT1 (PubMed:22383882). Interacts with host KEAP1; this interaction activates host transcription factor NRF2 by blocking its interaction with KEAP1 (PubMed:24630991). {ECO:0000269|PubMed:17928350, ECO:0000269|PubMed:22383882, ECO:0000269|PubMed:24630991, ECO:0000269|PubMed:25121748}.

Subcellular location: Virion membrane {ECO:0000269|PubMed:12525613}; Peripheral membrane protein {ECO:0000269|PubMed:12525613}. Host cell membrane {ECO:0000269|PubMed:12525613}; Peripheral membrane protein {ECO:0000269|PubMed:12525613}; Cytoplasmic side {ECO:0000269|PubMed:12525613}. Host endomembrane system {ECO:0000269|PubMed:12525613}; Peripheral membrane protein {ECO:0000269|PubMed:12525613}. Note=In virion, localizes on the intravirional side of the membrane. In the host cell, it is found associated with virus-induced membrane proliferation foci and to the plasma membrane where budding takes place (By similarity). {ECO:0000250}.

Similarity: Belongs to the filoviridae membrane-associated protein VP24 family. {ECO:0000305}.

Annotations taken from UniProtKB at the EBI.


Organism:		Zaire ebolavirus (strain Mayinga-76) (ZEBOV) (Zaire Ebola virus).
Taxonomy:		Viruses; Riboviria; Orthornavirae; Negarnaviricota; Haploviricotina; Monjiviricetes; Mononegavirales; Filoviridae; Ebolavirus.



Function:		Prevents the establishment of cellular antiviral state by blocking the interferon-alpha/beta (IFN-alpha/beta) and IFN-gamma signaling pathways. Blocks the IFN-induced nuclear accumulation of host phosphorylated STAT1 by interacting with the STAT1-binding region of host importins. Alternatively interacts also directly with host STAT1 and may additionally inhibit its non-phosphorylated form. Plays a role in assembly of viral nucleocapsid and virion budding. May act as a minor matrix protein that plays a role in assembly of viral nucleocapsid and virion budding. {ECO:0000269\|PubMed:12191476, ECO:0000269\|PubMed:12525613, ECO:0000269\|PubMed:15220407, ECO:0000269\|PubMed:17928350, ECO:0000269\|PubMed:25121748}.


Subunit:		Interacts with host importins KPNA1, KPNA5 and KPNA6 (PubMed:17928350, PubMed:25121748,PubMed:27974555). Interacts with host STAT1 (PubMed:22383882). Interacts with host KEAP1; this interaction activates host transcription factor NRF2 by blocking its interaction with KEAP1 (PubMed:24630991). {ECO:0000269\|PubMed:17928350, ECO:0000269\|PubMed:22383882, ECO:0000269\|PubMed:24630991, ECO:0000269\|PubMed:25121748}.
Subcellular location:		Virion membrane {ECO:0000269\|PubMed:12525613}; Peripheral membrane protein {ECO:0000269\|PubMed:12525613}. Host cell membrane {ECO:0000269\|PubMed:12525613}; Peripheral membrane protein {ECO:0000269\|PubMed:12525613}; Cytoplasmic side {ECO:0000269\|PubMed:12525613}. Host endomembrane system {ECO:0000269\|PubMed:12525613}; Peripheral membrane protein {ECO:0000269\|PubMed:12525613}. Note=In virion, localizes on the intravirional side of the membrane. In the host cell, it is found associated with virus-induced membrane proliferation foci and to the plasma membrane where budding takes place (By similarity). {ECO:0000250}.
Similarity:		Belongs to the filoviridae membrane-associated protein VP24 family. {ECO:0000305}.