PDBsum entry 4ts8

Transferase

PDB id

4ts8

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Contents

			Protein chain

					112 a.a.

			Ligands

					EDO ×2


					XZ8

			Waters ×98

PDB id:

4ts8

Links

Name:

Transferase

Title:

Crystal structure of the bromodomain of human crebbp in complex with xz08

Structure:

Creb-binding protein. Chain: a. Fragment: kinase domain, residues 1081-1197. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: crebbp, cbp. Expressed in: escherichia coli. Expression_system_taxid: 469008.

Resolution:

2.00Å

R-factor:

0.211

R-free:

0.254

Authors:

J.Dong,L.Gartenmann,D.Spiliotopoulos,A.Caflisch

Key ref:

J.Dong et al. Crystal structure of the bromodomain of human crebbp complex with xz08. To be published, .

Date:

18-Jun-14

Release date:

01-Jul-15

PROCHECK

	Headers

	References

Protein chain

Q92793 (CBP_HUMAN) - CREB-binding protein from Homo sapiens

Seq: Struc:

Seq: Struc:

Seq: Struc:

Seq: Struc:

Seq: Struc:					2442 a.a. 112 a.a.

Key:

PfamA domain

Secondary structure

CATH domain



		Enzyme reactions

Enzyme class 1:

E.C.2.3.1.- - ?????

[IntEnz] [ExPASy] [KEGG] [BRENDA]

Enzyme class 2:

E.C.2.3.1.48 - histone acetyltransferase.

[IntEnz] [ExPASy] [KEGG] [BRENDA]

Reaction:

L-lysyl-[protein] + acetyl-CoA = N₆-acetyl-L-lysyl-[protein] + CoA + H⁺

L-lysyl-[protein]	+	acetyl-CoA	=	N(6)-acetyl-L-lysyl-[protein]	+	CoA	+	H(+)

Note, where more than one E.C. class is given (as above), each may correspond to a different protein domain or, in the case of polyprotein precursors, to a different mature protein.

Molecule diagrams generated from .mol files obtained from the KEGG ftp site