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UniProt functional annotation for A6QP16 | ||
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| UniProt code: A6QP16. |
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| Organism: | |
Bos taurus (Bovine). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos. |
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| Function: | |
Specifically hydrolyzes 'Lys-29'-linked and 'Lys-33'-linked diubiquitin. Also cleaves 'Lys-63'-linked chains, but with 40-fold less efficiency compared to 'Lys-29'-linked ones. Positive regulator of the Wnt signaling pathway that deubiquitinates APC protein, a negative regulator of Wnt-mediated transcription. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the stress fiber dynamics and cell migration. May also modulate TNF-alpha signaling (By similarity). {ECO:0000250}. |
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| Catalytic activity: | |
Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76- residue protein attached to proteins as an intracellular targeting signal).; EC=3.4.19.12; |
| Subunit: | |
Interacts with APC and TRAF6. {ECO:0000250}. |
| Subcellular location: | |
Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Enriched in punctate localization in the cytoplasm. {ECO:0000250}. |
| Domain: | |
The OTU domain mediates the deubiquitinating activity. {ECO:0000250}. |
| Domain: | |
The RanBP2-type zinc fingers mediate the specific interaction with 'Lys-63'-linked ubiquitin. {ECO:0000250}. |
| Domain: | |
The second ankyrin repeat ANK 2 is termed AnkUBD, it interacts with ubiquitin hydrophobic patch and contributes to linkage specificity. {ECO:0000250}. |
| Domain: | |
The RanBP2-type zinc fingers, also called NZFs, may provide additional ubiquitin-binding sites when hydrolyzing long 'Lys-63'- linked chains. {ECO:0000250}. |
| Similarity: | |
Belongs to the peptidase C64 family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.