PDBsum entry 4s0u

Immune system

PDB id: 4s0u

Contents

Protein chains

124 a.a.

175 a.a.

Waters ×88

PDB id:

4s0u

Name:

Immune system

Title:

Crystal structure of nkg2d in complex with ulbp6

Structure:

Nkg2-d type ii integral membrane protein. Chain: a, b. Fragment: unp residues 90-215. Synonym: killer cell lectin-like receptor subfamily k member 1, nk cell receptor d, nkg2-d-activating nk receptor. Engineered: yes. Retinoic acid early transcript 1l protein. Chain: c. Fragment: unp residues 29-203.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: d12s2489e, klrk1, nkg2d. Expressed in: escherichia coli. Expression_system_taxid: 469008. Gene: raet1l, ulbp6. Expression_system_taxid: 562.

Resolution:

2.35Å R-factor: 0.241 R-free: 0.286

Authors:

F.Mohammed,B.E.Willcox

Key ref:

J.Zuo et al. (2017). A disease-Linked ulbp6 polymorphism inhibits nkg2d-Me target cell killing by enhancing the stability of nkg ligand binding.. Sci signal, 10, . PubMed id: 28559451

Date:

06-Jan-15 Release date: 20-Apr-16

Protein chains

P26718  (NKG2D_HUMAN) -  NKG2-D type II integral membrane protein from Homo sapiens

Seq: 216 a.a.

Struc: 124 a.a.

Protein chain

Q5VY80  (ULBP6_HUMAN) -  UL16-binding protein 6 from Homo sapiens

Seq: 246 a.a.

Struc: 175 a.a.*

* PDB and UniProt seqs differ at 1 residue position (black cross)