PDBsum entry 4rtx

Protein binding

PDB id: 4rtx

Contents

Protein chains

61 a.a.

Ligands

SO4 ×4

EPE ×2

Metals

_NI ×4

Waters ×301

PDB id:

4rtx

Name:

Protein binding

Title:

Crystal structure of the src tyrosine kinase sh3 domain t96g/q128r mutant

Structure:

Proto-oncogene tyrosine-protein kinase src. Chain: a, b, c, d. Fragment: sh3 domain (unp residue 85-141). Synonym: proto-oncogenE C-src, pp60c-src, p60-src. Engineered: yes. Mutation: yes

Source:

Gallus gallus. Bantam,chickens. Organism_taxid: 9031. Gene: src. Expressed in: escherichia coli. Expression_system_taxid: 469008.

Resolution:

1.32Å R-factor: 0.173 R-free: 0.207

Authors:

A.Camara-Artigas

Key ref:

A.Camara-Artigas Crystal structure of the src tyrosine kinase sh3 doma t96g/q128r mutant. To be published, .

Date:

16-Nov-14 Release date: 28-Oct-15

Protein chains

P00523  (SRC_CHICK) -  Proto-oncogene tyrosine-protein kinase Src from Gallus gallus

Seq: 533 a.a.

Struc: 61 a.a.*

* PDB and UniProt seqs differ at 5 residue positions (black crosses)

Enzyme reactions

• Enzyme class: E.C.2.7.10.2 - non-specific protein-tyrosine kinase.
• Reaction: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H⁺

Molecule diagrams generated from .mol files obtained from the KEGG ftp site