PDBsum entry 4rtv

Protein binding, signaling protein

PDB id: 4rtv

Contents

Protein chains

57 a.a.

11 a.a.

Waters ×33

PDB id:

4rtv

Name:

Protein binding, signaling protein

Title:

Crystal structure of the src tyrosine kinase sh3 domain s94a/q128r mutant in complex with the high affinity synthetic peptide app12

Structure:

Proto-oncogene tyrosine-protein kinase src. Chain: a. Fragment: sh3 domain (unp residues 85-141). Synonym: proto-oncogenE C-src, pp60c-src, p60-src. Engineered: yes. Mutation: yes. App12 peptide. Chain: b. Engineered: yes

Source:

Gallus gallus. Bantam,chickens. Organism_taxid: 9031. Gene: src. Expressed in: escherichia coli. Expression_system_taxid: 469008. Synthetic: yes. Organism_taxid: 32630. Other_details: synthetic high affinity peptide

Resolution:

1.37Å R-factor: 0.151 R-free: 0.178

Authors:

A.Camara-Artigas,J.Bacarizo

Key ref:

A.Camara-Artigas Crystal structure of the src tyrosine kinase sh3 doma s94a/q128r mutant in complex with the high affinity synthetic peptide app12. To be published, .

Date:

16-Nov-14 Release date: 28-Oct-15

Protein chain

P00523  (SRC_CHICK) -  Proto-oncogene tyrosine-protein kinase Src from Gallus gallus

Seq: 533 a.a.

Struc: 57 a.a.*

Protein chain

No UniProt id for this chain

Struc: 10 a.a.

* PDB and UniProt seqs differ at 3 residue positions (black crosses)

Enzyme reactions

• Enzyme class: Chain A: E.C.2.7.10.2 - non-specific protein-tyrosine kinase.
• Reaction: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H⁺

Molecule diagrams generated from .mol files obtained from the KEGG ftp site