PDBsum entry 4qxf

Membrane protein

PDB id: 4qxf

Contents

Protein chains

300 a.a.

78 a.a.

Waters ×263

PDB id:

4qxf

Name:

Membrane protein

Title:

Crystal structure of human lgr4 and rspo1

Structure:

Leucine-rich repeat-containing g-protein coupled receptor 4, variable lymphocyte receptor b. Chain: a, b. Fragment: unp residues 27-252, unp residues 128-200. Synonym: g-protein coupled receptor 48. Engineered: yes. Mutation: yes. Other_details: chimera of (leucine-rich repeat-containing g-protein coupled receptor 4 and variable lymphocyte receptor b).

Source:

Homo sapiens, eptatretus burgeri. Human, inshore hagfish. Organism_taxid: 9606, 7764. Gene: gpr48, lgr4, vlrb. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Homo sapiens. Human. Organism_taxid: 9606.

Resolution:

2.25Å R-factor: 0.215 R-free: 0.243

Authors:

J.G.Xu,C.Huang,Y.Zhou,Y.Zhu

Key ref:

J.G.Xu et al. Crystal structure of human lgr4 and rspo1. To be published, .

Date:

20-Jul-14 Release date: 08-Oct-14

Protein chains

Q4G1L2  (Q4G1L2_EPTBU) -  Variable lymphocyte receptor B from Eptatretus burgeri

Seq: 273 a.a.

Struc: 300 a.a.*

Protein chains

Q9BXB1  (LGR4_HUMAN) -  Leucine-rich repeat-containing G-protein coupled receptor 4 from Homo sapiens

Seq: 951 a.a.

Struc: 300 a.a.*

Protein chains

Q2MKA7  (RSPO1_HUMAN) -  R-spondin-1 from Homo sapiens

Seq: 263 a.a.

Struc: 78 a.a.

* PDB and UniProt seqs differ at 153 residue positions (black crosses)