PDBsum entry 4qsy

Hydrolase/protein binding

PDB id: 4qsy

Contents

Protein chains

100 a.a.

11 a.a.

Waters ×53

PDB id:

4qsy

Name:

Hydrolase/protein binding

Title:

Shp2 sh2 domain in complex with gab1 peptide

Structure:

Tyrosine-protein phosphatase non-receptor type 11. Chain: a. Fragment: sh2 domain, unp residues 1-104. Synonym: protein-tyrosine phosphatase 1d, ptp-1d, protein-tyrosine phosphatase 2c, ptp-2c, sh-ptp2, shp-2, shp2, sh-ptp3. Engineered: yes. Grb2-associated-binding protein 1. Chain: b. Fragment: phospho peptide, unp residues 621-633.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: ptpn11, ptp2c, shptp2. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Other_details: this sequence occurs naturally in humans.

Resolution:

2.10Å R-factor: 0.201 R-free: 0.229

Authors:

G.Gogl,A.Remenyi

Key ref:

G.Gogl and a.remenyi Selective targeting of gab adapter protein shp2 tyros phosphatase interaction attenuates erk signaling. To be published, .

Date:

06-Jul-14 Release date: 08-Jul-15

Protein chain

Q06124  (PTN11_HUMAN) -  Tyrosine-protein phosphatase non-receptor type 11 from Homo sapiens

Seq: 593 a.a.

Struc: 100 a.a.

Protein chain

Q13480  (GAB1_HUMAN) -  GRB2-associated-binding protein 1 from Homo sapiens

Seq: 694 a.a.

Struc: 11 a.a.

Enzyme reactions

• Enzyme class: Chain A: E.C.3.1.3.48 - protein-tyrosine-phosphatase.
• Reaction: O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate

Molecule diagrams generated from .mol files obtained from the KEGG ftp site