UniProt functional annotation for Q6PL18



	UniProt functional annotation for Q6PL18

UniProt code: Q6PL18.

Organism: Homo sapiens (Human).

Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.

Function: May be a transcriptional coactivator of the nuclear receptor ESR1 required to induce the expression of a subset of estradiol target genes, such as CCND1, MYC and E2F1. May play a role in the recruitment or occupancy of CREBBP at some ESR1 target gene promoters. May be required for histone hyperacetylation. Involved in the estrogen-induced cell proliferation and cell cycle progression of breast cancer cells. {ECO:0000269|PubMed:17998543}.

Catalytic activity: Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216;

Subunit: Interacts with ESR1 and NCOA3 and these interactions are enhanced by estradiol. Interacts with acetylated lysine residues on histone H1.4, H2A, H2B and H3 (in vitro). {ECO:0000269|PubMed:17998543, ECO:0000269|PubMed:22464331}.

Subcellular location: Nucleus {ECO:0000269|PubMed:17998543}.

Tissue specificity: Highly expressed in estrogen receptor positive breast tumors and in osteosarcoma tumors. {ECO:0000269|PubMed:15721472, ECO:0000269|PubMed:17076897, ECO:0000269|PubMed:17660802}.

Induction: Up-regulated in breast, uterus, colon, ovary, and stomach tumors. Induced in breast cancer cells overexpressing NCOA3 or treated with estrogen. Down-regulated in 5-fluorouracil-resistant derivatives of the colon cancer cell line HCT 116. {ECO:0000269|PubMed:15334068, ECO:0000269|PubMed:16709241, ECO:0000269|PubMed:17998543}.

Miscellaneous: [Isoform 2]: Dubious isoform. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.

Similarity: Belongs to the AAA ATPase family. {ECO:0000305}.

Sequence caution: Sequence=AAF22032.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH10686.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the N-terminal part (676-679).; Evidence={ECO:0000305}; Sequence=AAH19909.1; Type=Erroneous initiation; Evidence={ECO:0000305};

Annotations taken from UniProtKB at the EBI.


Organism:		Homo sapiens (Human).
Taxonomy:		Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.



Function:		May be a transcriptional coactivator of the nuclear receptor ESR1 required to induce the expression of a subset of estradiol target genes, such as CCND1, MYC and E2F1. May play a role in the recruitment or occupancy of CREBBP at some ESR1 target gene promoters. May be required for histone hyperacetylation. Involved in the estrogen-induced cell proliferation and cell cycle progression of breast cancer cells. {ECO:0000269\|PubMed:17998543}.


Catalytic activity:		Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216;
Subunit:		Interacts with ESR1 and NCOA3 and these interactions are enhanced by estradiol. Interacts with acetylated lysine residues on histone H1.4, H2A, H2B and H3 (in vitro). {ECO:0000269\|PubMed:17998543, ECO:0000269\|PubMed:22464331}.
Subcellular location:		Nucleus {ECO:0000269\|PubMed:17998543}.
Tissue specificity:		Highly expressed in estrogen receptor positive breast tumors and in osteosarcoma tumors. {ECO:0000269\|PubMed:15721472, ECO:0000269\|PubMed:17076897, ECO:0000269\|PubMed:17660802}.
Induction:		Up-regulated in breast, uterus, colon, ovary, and stomach tumors. Induced in breast cancer cells overexpressing NCOA3 or treated with estrogen. Down-regulated in 5-fluorouracil-resistant derivatives of the colon cancer cell line HCT 116. {ECO:0000269\|PubMed:15334068, ECO:0000269\|PubMed:16709241, ECO:0000269\|PubMed:17998543}.
Miscellaneous:		[Isoform 2]: Dubious isoform. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.
Similarity:		Belongs to the AAA ATPase family. {ECO:0000305}.
Sequence caution:		Sequence=AAF22032.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH10686.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the N-terminal part (676-679).; Evidence={ECO:0000305}; Sequence=AAH19909.1; Type=Erroneous initiation; Evidence={ECO:0000305};