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PDBsum entry 4qrr
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Immune system
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PDB id
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4qrr
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Contents |
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276 a.a.
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99 a.a.
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203 a.a.
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241 a.a.
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References listed in PDB file
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Key reference
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Title
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The molecular bases of δ/αβ t cell-Mediated antigen recognition.
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Authors
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D.G.Pellicci,
A.P.Uldrich,
J.Le nours,
F.Ross,
E.Chabrol,
S.B.Eckle,
R.De boer,
R.T.Lim,
K.Mcpherson,
G.Besra,
A.R.Howell,
L.Moretta,
J.Mccluskey,
M.H.Heemskerk,
S.Gras,
J.Rossjohn,
D.I.Godfrey.
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Ref.
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J Exp Med, 2014,
211,
2599-2615.
[DOI no: ]
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PubMed id
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Abstract
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αβ and γδ T cells are disparate T cell lineages that can respond to distinct
antigens (Ags) via the use of the αβ and γδ T cell Ag receptors (TCRs),
respectively. Here we characterize a population of human T cells, which we term
δ/αβ T cells, expressing TCRs comprised of a TCR-δ variable gene (Vδ1)
fused to joining α and constant α domains, paired with an array of TCR-β
chains. We demonstrate that these cells, which represent ∼50% of all Vδ1(+)
human T cells, can recognize peptide- and lipid-based Ags presented by human
leukocyte antigen (HLA) and CD1d, respectively. Similar to type I natural killer
T (NKT) cells, CD1d-lipid Ag-reactive δ/αβ T cells recognized
α-galactosylceramide (α-GalCer); however, their fine specificity for other
lipid Ags presented by CD1d, such as α-glucosylceramide, was distinct from type
I NKT cells. Thus, δ/αβTCRs contribute new patterns of Ag specificity to the
human immune system. Furthermore, we provide the molecular bases of how
δ/αβTCRs bind to their targets, with the Vδ1-encoded region providing a
major contribution to δ/αβTCR binding. Our findings highlight how components
from αβ and γδTCR gene loci can recombine to confer Ag specificity, thus
expanding our understanding of T cell biology and TCR diversity.
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