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UniProt functional annotation for P26954 | ||
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| UniProt code: P26954. |
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| Organism: | |
Mus musculus (Mouse). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus. |
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| Function: | |
In mouse, there are two classes of high-affinity IL3 receptors. One contains this IL3-specific beta subunit and the other contains the beta subunit also shared by high-affinity IL5 and GM-CSF receptors. |
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| Subunit: | |
Heterodimer of an alpha and a beta subunit. |
| Subcellular location: | |
Membrane; Single-pass type I membrane protein. |
| Domain: | |
The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding. |
| Domain: | |
The box 1 motif is required for JAK interaction and/or activation. |
| Similarity: | |
Belongs to the type I cytokine receptor family. Type 4 subfamily. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.