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UniProt functional annotation for Q8WXC3 | ||
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| UniProt code: Q8WXC3. |
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| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
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| Function: | |
Associates with PYCARD/ASC and modulates its ability to collaborate with MEFV/pyrin and NLRP3/cryopyrin in NF-kappa-B and pro- caspase-1 activation. Suppresses kinase activity of NF-kappa-B inhibitor kinase (IKK) complex, expression of NF-kappa-B inducible genes and inhibits NF-kappa-B activation by cytokines and LPS. {ECO:0000269|PubMed:12656673, ECO:0000269|PubMed:24871464}. |
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| Subunit: | |
Interacts with PYCARD/ASC (via pyrin domain). {ECO:0000269|PubMed:12656673, ECO:0000269|PubMed:17178784}. |
| Subcellular location: | |
Cytoplasm {ECO:0000269|PubMed:12656673}. Note=Recruited to specks formed by PYCARD within the cytoplasm. {ECO:0000269|PubMed:17178784}. |
| Tissue specificity: | |
Predominantly expressed in monocytes, macrophages and granulocytes. {ECO:0000269|PubMed:12656673}. |
| Ptm: | |
Phosphorylated. {ECO:0000269|PubMed:12656673}. |
Annotations taken from UniProtKB at the EBI.