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PDBsum entry 4qkj
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Immune system
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PDB id
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4qkj
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References listed in PDB file
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Key reference
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Title
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Four crystal structures of human llt1, A ligand of human nkr-P1, In varied glycosylation and oligomerization states.
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Authors
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T.Skálová,
J.Bláha,
K.Harlos,
J.Dušková,
T.Koval',
J.Stránský,
J.Hašek,
O.Vaněk,
J.Dohnálek.
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Ref.
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Acta Crystallogr D Biol Crystallogr, 2015,
71,
578-591.
[DOI no: ]
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PubMed id
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Abstract
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Human LLT1 is a C-type lectin-like ligand of NKR-P1 (CD161, gene KLRB1), a
C-type lectin-like receptor of natural killer cells. Using X-ray diffraction,
the first experimental structures of human LLT1 were determined. Four structures
of LLT1 under various conditions were determined: monomeric, dimeric
deglycosylated after the first N-acetylglucosamine unit in two forms and
hexameric with homogeneous GlcNAc2Man5 glycosylation. The dimeric form follows
the classical dimerization mode of human CD69. The monomeric form keeps the same
fold with the exception of the position of an outer part of the long loop
region. The hexamer of glycosylated LLT1 consists of three classical dimers. The
hexameric packing may indicate a possible mode of interaction of C-type
lectin-like proteins in the glycosylated form.
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