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UniProt functional annotation for Q9UHP7 | ||
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| UniProt code: Q9UHP7. |
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| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
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| Function: | |
Receptor for KLRB1 that protects target cells against natural killer cell-mediated lysis (PubMed:20843815, PubMed:16339513). Inhibits osteoclast formation (PubMed:14753741, PubMed:15123656). Inhibits bone resorption (PubMed:14753741). Modulates the release of interferon-gamma (PubMed:15104121). Binds high molecular weight sulfated glycosaminoglycans (PubMed:15123656). {ECO:0000269|PubMed:14753741, ECO:0000269|PubMed:15104121, ECO:0000269|PubMed:15123656, ECO:0000269|PubMed:16339513, ECO:0000269|PubMed:20843815}. |
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| Subunit: | |
Homodimer; disulfide-linked. {ECO:0000269|PubMed:15104121, ECO:0000269|PubMed:20843815, ECO:0000269|PubMed:25760607, ECO:0000269|PubMed:25826155}. |
| Subcellular location: | |
Cell membrane {ECO:0000269|PubMed:15104121, ECO:0000269|PubMed:20843815, ECO:0000305|PubMed:16339513}; Single-pass type II membrane protein {ECO:0000255}. |
| Subcellular location: | |
[Isoform 2]: Endoplasmic reticulum {ECO:0000269|PubMed:20843815}. |
| Subcellular location: | |
[Isoform 4]: Endoplasmic reticulum {ECO:0000269|PubMed:20843815}. |
| Tissue specificity: | |
Detected in peripheral blood leukocytes, osteoblasts, lymph node, thymus and spleen. Isoform 1, isoform 2 and isoform 4 are expressed in T- and B-lymphocytes, and at lower levels in NK cells. They are also expressed in B-cell lines and LPS-matured monocyte-derived dendritic cells. {ECO:0000269|PubMed:10541800, ECO:0000269|PubMed:20843815}. |
| Induction: | |
Up-regulated by IL1A/interleukin-1 alpha and prostaglandin E2 in cultured osteogenic sarcoma cells. {ECO:0000269|PubMed:14753741}. |
| Ptm: | |
N-glycosylated. {ECO:0000269|PubMed:15104121, ECO:0000269|PubMed:20843815, ECO:0000269|PubMed:25760607}. |
Annotations taken from UniProtKB at the EBI.