PDBsum entry 4qib

Isomerase

PDB id: 4qib

Contents

Protein chain

145 a.a.

Ligands

PE4

SO4 ×4

Waters ×202

PDB id:

4qib

Name:

Isomerase

Title:

Oxidation-mediated inhibition of the peptidyl-prolyl isomerase pin1

Structure:

Peptidyl-prolyl cis-trans isomerase nima-interacting 1. Chain: a. Synonym: peptidyl-prolyl cis-trans isomerase pin1, ppiase pin1, rotamase pin1. Engineered: yes. Mutation: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: pin1. Expressed in: escherichia coli. Expression_system_taxid: 562.

Resolution:

1.87Å R-factor: 0.156 R-free: 0.185

Authors:

B.T.Innes,M.A.Sowole,L.Konermann,D.W.Litchfield,C.J.Brandl, B.H.Shilton

Key ref:

B.T.Innes et al. (2015). Peroxide-mediated oxidation and inhibition of the peptidyl-prolyl isomerase Pin1. Biochim Biophys Acta, 1852, 905-912. PubMed id: 25595659 DOI: 10.1016/j.bbadis.2014.12.025

Date:

30-May-14 Release date: 04-Feb-15

Protein chain

Q13526  (PIN1_HUMAN) -  Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 from Homo sapiens

Seq: 163 a.a.

Struc: 145 a.a.*

* PDB and UniProt seqs differ at 2 residue positions (black crosses)

Enzyme reactions

• Enzyme class: E.C.5.2.1.8 - peptidylprolyl isomerase.
• Reaction: [protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)

Molecule diagrams generated from .mol files obtained from the KEGG ftp site

Added reference

DOI no: 10.1016/j.bbadis.2014.12.025

Biochim Biophys Acta 1852:905-912 (2015)

PubMed id: 25595659

Peroxide-mediated oxidation and inhibition of the peptidyl-prolyl isomerase Pin1.

B.T.Innes, M.A.Sowole, L.Gyenis, M.Dubinsky, L.Konermann, D.W.Litchfield, C.J.Brandl, B.H.Shilton.

ABSTRACT

No abstract given.