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UniProt functional annotation for Q6UWY2 | ||
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| UniProt code: Q6UWY2. |
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| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
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| Function: | |
Serine protease that cleaves preferentially after Arg residues (PubMed:22474388, PubMed:23904161, PubMed:25156428). Can also cleave after citrulline (deimidated arginine) and methylarginine residues (PubMed:25156428). {ECO:0000269|PubMed:22474388, ECO:0000269|PubMed:23904161, ECO:0000269|PubMed:25156428}. |
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| Activity regulation: | |
Inhibited by SERPINA1, SERPINC1 and SERPING1. {ECO:0000269|PubMed:22474388}. |
| Subcellular location: | |
Cytoplasmic granule lumen {ECO:0000269|PubMed:22474388, ECO:0000269|PubMed:23904161}. Secreted {ECO:0000269|PubMed:22474388, ECO:0000269|PubMed:23904161}. Note=Stored in cytoplasmic granules and secreted as active enzyme in response to stimulation of neutrophils. {ECO:0000269|PubMed:22474388}. |
| Tissue specificity: | |
Detected in peripheral blood neutrophil granulocytes, but not in other types of leukocytes. Detected in neutrophils and neutrophil precursors in bone marrow (at protein level) (PubMed:22474388, PubMed:23904161). Detected in myeloblasts and promyelocytes in bone marrow (PubMed:23904161). {ECO:0000269|PubMed:22474388, ECO:0000269|PubMed:23904161}. |
| Ptm: | |
After cleavage of the signal peptide, the N-terminus is probably further processed by CTSC (PubMed:22474388, PubMed:23904161). Processing by CTSC is probably required for accumulation in cytoplasmic granules; in the absence of CTSC the protein does not accumulate (PubMed:23904161). {ECO:0000269|PubMed:23904161, ECO:0000305|PubMed:22474388}. |
| Ptm: | |
N-glycosylated. {ECO:0000269|PubMed:23904161}. |
| Similarity: | |
Belongs to the peptidase S1 family. {ECO:0000255|PROSITE- ProRule:PRU00274}. |
Annotations taken from UniProtKB at the EBI.