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PDBsum entry 4q48
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DNA binding protein
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PDB id
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4q48
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References listed in PDB file
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Key reference
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Title
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Crystal structure of deinococcus radiodurans recq helicase catalytic core domain: the interdomain flexibility.
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Authors
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S.C.Chen,
C.H.Huang,
C.S.Yang,
T.D.Way,
M.C.Chang,
Y.Chen.
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Ref.
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Biomed Res Int, 2014,
2014,
342725.
[DOI no: ]
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PubMed id
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Abstract
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RecQ DNA helicases are key enzymes in the maintenance of genome integrity, and
they have functions in DNA replication, recombination, and repair. In contrast
to most RecQs, RecQ from Deinococcus radiodurans (DrRecQ) possesses an unusual
domain architecture that is crucial for its remarkable ability to repair DNA.
Here, we determined the crystal structures of the DrRecQ helicase catalytic core
and its ADP-bound form, revealing interdomain flexibility in its first RecA-like
and winged-helix (WH) domains. Additionally, the WH domain of DrRecQ is
positioned in a different orientation from that of the E. coli RecQ (EcRecQ).
These results suggest that the orientation of the protein during DNA-binding is
significantly different when comparing DrRecQ and EcRecQ.
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