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UniProt functional annotation for Q8NDX5 | ||
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| UniProt code: Q8NDX5. |
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| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
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| Function: | |
Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. {ECO:0000269|PubMed:12167701}. |
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| Subunit: | |
Component of a PRC1-like complex. {ECO:0000269|PubMed:12167701, ECO:0000269|PubMed:19636380, ECO:0000269|PubMed:21282530}. |
| Subcellular location: | |
Nucleus {ECO:0000269|PubMed:12167701, ECO:0000269|PubMed:21282530}. |
| Miscellaneous: | |
The hPRC-H complex purification reported by PubMed:12167701 probably presents a mixture of different PRC1-like complexes. |
| Sequence caution: | |
[Isoform 5]: Sequence=BAB14245.1; Type=Frameshift; Evidence={ECO:0000305}; |
Annotations taken from UniProtKB at the EBI.